I mean basically anything can, there was a time in the early 2010s where the word “Atze” came up as a way to say homie, which was attributed to some rappers using it. Funnily enough the term came from the 1700s iirc.

Would I be right in thinking people would find it weird in maybe the same way that people find it weird when you say “lol” irl?

Yes, similar, maybe ‘zuhausys’ would be even more obscure.